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. 2016 Jan 13;115(3):1446–1457. doi: 10.1152/jn.00283.2015

Table 1.

Nitrergic drugs on pro-metamorphic stages (stage 48+)

SNAP
DEA-NO
l-NAME
PTIO
Tissue Exposed/Parameter Control Drug Wash Control Drug Wash Control Drug Wash Control Drug Wash
Whole preparation
    Swim, % 4.25 ± 2.03 14.33 ± 5.82 7.34 ± 3.42 1.06 ± 0.34 3.01 ± 0.72 1.73 ± 0.39 10.42 ± 1.60 4.33 ± 0.88 7.91 ± 1.52 4.62 ± 1.60 1.37 ± 0.37 3.52 ± 10.65
    Burst duration, ms 82.40 ± 7.66 89.39 ± 8.87 89.07 ± 7.93 128.20 ± 33.99 107.50 ± 21.29 109.81 ± 19.93 70.35 ± 7.69 79.54 ± 9.19 73.00 ± 5.16 70.90 ± 7.13 91.02 ± 18.85 82.38 ± 12.29
    Cycle period, ms 195.68 ± 11.18 223.92 ± 15.97 200.56 ± 13.19 211.78 ± 16.24 213.27 ± 11.02 217.45 ± 17.88 196.57 ± 7.58 204.31 ± 12.47 198.56 ± 11.66 197.88 ± 15.10 207.19 ± 17.97 206.01 ± 14.87
    Episode duration, s 4.25 ± 2.03 14.33 ± 5.82 7.34 ± 3.42 1.06 ± 0.34 3.01 ± 0.72 1.73 ± 0.39 10.42 ± 1.60 4.33 ± 0.88 7.91 ± 1.52 5.23 ± 1.15 5.03 ± 1.28 3.66 ± 0.61
SNAP and DEA-NO
l-NAME and PTIO
Control Drug Wash Control Drug Wash
Spinal cord
    Swim, % 2.92 ± 2.02 2.46 ± 1.83 1.02 ± 0.49 1.15 ± 0.31 0.86 ± 0.14 0.90 ± 0.18
    Burst duration, ms 89.42 ± 12.09 96.17 ± 18.50 85.00 ± 7.67 90.64 ± 12.77 107.01 ± 19.95 90.70 ± 13.61
    Cycle period, ms 252.35 ± 13.67 268.73 ± 32.86 239.38 ± 18.00 206.64 ± 18.25 220.85 ± 21.37 186.63 ± 17.24
    Episode duration, s 3.46 ± 0.98 2.38 ± 0.44 2.55 ± 0.49 2.49 ± 0.79 2.56 ± 0.89 3.40 ± 1.10
Brain stem
    Swim, % 1.04 ± 0.48 1.61 ± 0.44 1.01 ± 0.40 3.97 ± 3.14 0.44 ± 0.20 3.59 ± 2.86
    Burst duration, ms 85.00 ± 7.67 98.26 ± 12.68 81.60 ± 6.08 93.39 ± 11.81 110.98 ± 18.73 83.99 ± 8.68
    Cycle period, ms 239.38 ± 18.00 251.09 ± 24.12 220.50 ± 11.86 168.96 ± 11.90 178.18 ± 17.90 180.46 ± 7.87
    Episode duration, s 2.49 ± 0.49 2.22 ± 0.28 3.11 ± 0.85 2.59 ± 0.90 2.44 ± 1.53 2.57 ± 0.77

Values are means ± SE. SNAP, S-nitroso-N-acetyl penicillamine; DEA-NO, diethylamine NONOate; l-NAME, Nω-nitro-l-arginine methyl ester; PTIO, 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide.