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. 2015 Dec 30;115(3):1389–1398. doi: 10.1152/jn.00387.2015

Fig. 4.

Fig. 4.

Olanzapine effect on activity of liver- and stomach-related DMV neurons. A: retrograde transsynaptic labeling was used to identify stomach- and liver-related DMV neurons. Recordings from the organ-specific neurons were conducted ∼72 h after inoculation of the stomach and liver. Left: stomach-labeled DMV neurons identified on the basis of their red fluorescence (arrows). Center: liver-related DMV neurons identified on the basis of their green fluorescence (arrowheads). Right: merged image illustrating the recorded liver-related neuron after visualization with AMCA (arrow, blue). Stars indicate double-labeled (stomach and liver related) DMV neurons. Scale bar, 50 μm. B: summarized data illustrating RMP response of all nonidentified and stomach- and liver-related DMV neurons to olanzapine application. Red circles, hyperpolarized neurons (>2.5 mV); black circles, nonhyperpolarized DMV neurons. Average value is based on all cells. C: combined data demonstrating effect of olanzapine on action potential firing rate in all nonidentified and stomach- and liver-related DMV neurons. Red, firing rate of hyperpolarized neurons; black, firing rate of nonhyperpolarized DMV neurons. Average is based on all recorded neurons. D: in all groups similar % of DMV neurons showed hyperpolarization after olanzapine application. *Significance (P < 0.05).