TABLE 1.
Fold change in LPV and RTV sensitivity for patient-derived clones and the corresponding Gag-protease mutants
| Patient no. | Site-directed mutation(s) in p8.MJ4 backbonea | Fold change in sensitivity of site-directed mutant clones |
|
|---|---|---|---|
| LPV | RTV | ||
| 1 | M46I + I54V + V82A + E428D | 5.9 | 16 |
| 2 | I54V + V82A + A431V | 3.2 | 11 |
| 3 | V82A + Q62S | 0.7 | 1.1 |
| 4 | M46I + I54V + V82A + N374S | 5.9 | 22 |
| 6 | S373A | 1.0 | 1.9 |
| 8 | V82A + N451S | 1.4 | 1.0 |
| 9 | M46I + V82A + F79H | 1.7 | 3.0 |
| 10 | I54V + V82A + A431V | 3.2 | 4.0 |
| 11 | L449P + P453L | 0.8 | 1.5 |
| 12 | V82A | 1.3 | 1.2 |
| 19 | T374A | 1.4 | 1.1 |
| 20 | L449P | 0.7 | 0.6 |
a
Protease amino acid changes are highlighted in bold, Gag CSs are in normal font, and non-CS amino acid changes are italicized.