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Dosing adjustments based on CLCR in the solid-organ transplant population of oral valganciclovir and i.v. ganciclovir
| Oral valganciclovir |
i.v. ganciclovir |
|||
|---|---|---|---|---|
| CLCR (ml/min) | Treatment dose | Prophylaxis dose | CLCR (ml/min) | Treatment dose |
| ≥60 | 900 mg/12 h | 900 mg/24 h | ≥70 | 5 mg/kg/12 h |
| 40–60 | 450 mg/12 h | 450 mg/24 h | 50–70 | 2.5 mg/kg/12 h |
| 25–40 | 450 mg/24 h | 450 mg/48 h | 25–50 | 2.5 mg/kg/24 h |
| 10–25 | 450 mg/48 h | 450 mg twice per week | 10–25 | 1.25 mg/kg/24 h |
