FIG 1.
Screen of selected α-hydroxytropolones at low concentrations. Vero cells were infected with a primary clinical isolate of HSV-1 or HSV-2 at an MOI of 0.1 in the presence of each compound or the diluent control and incubated for 24 h. Cultures were then collected, and the virus titer was determined by a plaque assay. The log10 reduction in plaque counts for each compound at 0.5 μM or 0.17 μM compared to the diluent control is shown. Values are the averages of data from duplicate samples ± ranges from one experiment.