FIG 5.

Preliminary SAR for α-hydroxytropolones against HSV-1 and HSV-2. (A) Anti-HSV data from lead natural-product α-hydroxytropolones from previous studies (33). Also shown are tropolone natural-product analogs that were inactive against HSV-1 and HSV-2 at 5 μM. n.d., not determined. (B) Qualitative comparison of HSV-1 suppression (>3 log₁₀ units) by closely related synthetic α-hydroxytropolones at 50 μM (+), 5 μM (++), and 0.5 μM (+++), highlighting a trend of increasing potency with larger substituents. (C) EC₅₀ and CC₅₀ values of synthetic α-hydroxytropolones, reported as averages of data from 2 runs.