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Mean plasma pyrazinamide (PZA) concentrations (μg/ml) after the intake of a mean dose of 33.3 mg/kg of PZA (n = 39). Adult target Cmax values, 20 to 50 μg/ml when PZA is administered at 25 mg/kg/day in American adults (23); Cmax, 52.7 μg/ml when INH is administered at 35.7 mg/kg in South African adults (24).
