TABLE 2.
Mutations identified in the resistance selection studies of NNRTIs with prevalent NNRTI-associated mutants
| Mutant | Additional mutation(s) selecteda |
||
|---|---|---|---|
| DOR | RPV | EFV | |
| K103N | None | L100I, V179I/T/A, Y181C, E138Q | L100I, V108I, L234I, V179A, M230I, P225H/S, Y188C, V90I, H221Y, F227L, K101Q |
| Y181C | None | V106I, H221Y, M230I, K101E, V179 M, V90I, V189I, F227C | None |
| K103N/Y181C | None | V90I, L100I , K101E V179L, H221Y | L100I, V108I, V179E, H221Y, P225H |
| G190A | None | None | None |
a
Mutants in bold represent the most frequent mutations identified in breakthrough viruses.