TABLE 1.
In vitro activities (EC50s) and SIs of the tested compounds against BT forms of Trypanosoma cruzi Y
| Compound | EC50 (μM) |
SI at 24 h | |
|---|---|---|---|
| 2 h | 24 h | ||
| 35DAP096 | >32 | >32 | >1 |
| 35DAP073 | 0.7 ± 0.14 | 0.5 ± 0.2a | 64 |
| 35DAP077 | 28 ± 0.3 | 10 ± 5.5 | 2 |
| 35DAP081 | 2 ± 0.8 | 0.6 ± 0.2a | 53 |
| 38DAP092 | 16 ± 11 | 7 ± 1.2a | 5 |
| 38DAP096 | >32 | 24 ± 1 | 1.3 |
| 19SAB003 | >32 | >32 | >1 |
| 19SAB005 | >32 | >32 | >1 |
| 19SAB007 | >32 | >32 | >1 |
| 28SMB008 | >32 | >32 | >1 |
| 23SMB046 | >32 | >32 | >1 |
| 23SMB050 | >32 | >32 | >1 |
| 26SMB060 | >32 | >32 | >1 |
| 27SMB005 | >32 | >32 | >1 |
| Benznidazole | >100 | 13 ± 2 | 77b |
a
P < 0.05 by ANOVA.
b
The datum is from Timm et al. (18).