TABLE 4.

Results of acute toxicity analysis^a

Compound	Result after treatment at the following dose (mg/kg):						NOAEL (mg/kg)
	0	12.5	25	50	100	200
35DAP073	NDE	NDE	NDE	Loss of mouse body wt	Tremors, ataxia	Death	25
35DAP081	NDE	Ataxia, tremors, excitation and vocalizationb	Ataxia, tremors, excitation and vocalizationb	Ataxia, tremors, excitation and vocalizationb	Ataxia, tremors, excitation and vocalizationb	Ataxia, tremors, excitation and vocalizationb	<12. 5

^aEscalating doses starting at 12.5 mg/kg and increasing to 200 mg/kg were administered i.p. in a 0.1-ml final volume to female Swiss Webster mice, using a single mouse per dose. NOAEL, no-observed-adverse-effect level (for noninvasive parameters); NDE, no detectable effect.

^bThese effects were observed after 2 h of compound administration.