TABLE 5.
Plasma biochemical analysis of female mice after 48 h of compound administration
| Biochemical marker | Compound | Result after treatment with the following dose (mg/kg)a: |
|||||
|---|---|---|---|---|---|---|---|
| 0b | 12.5 | 25 | 50 | 100 | 200 | ||
| ALT | 35DAP073 | 57 ± 8 | 58 ± 0 | 51 ± 0 | 88 ± 51 | 77 ± 41 | ND |
| 35DAP081 | 56 ± 0.7 | 67 ± 13 | 82 ± 8 | 102 ± 23 | 116 ± 11 | ||
| CK | 35DAP073 | 935 ± 226 | 635 ± 80 | 368 ± 0 | 701 ± 260 | 870 ± 646 | ND |
| 35DAP081 | 503 ± 145 | 509 ± 145 | 737 ± 0 | 1,681 ± 310 | 1,162 ± 452 | ||
| AST | 35DAP073 | 183 ± 16 | 109 ± 0 | 113 ± 0 | 152 ± 37 | 242 ± 105 | ND |
| 35DAP081 | 105 ± 16 | 143 ± 21 | 285 ± 55 | 422 ± 132 | 376 ± 229 | ||
| BUN | 35DAP073 | 46 ± 11 | 51 ± 16 | 34 ± 0 | 43 ± 2 | 55 ± 12 | ND |
| 35DAP081 | 37 ± 7 | 29 ± 7 | 31 ± 10 | 29 ± 0 | 60 ± 29 | ||
a
Data are in milligrams per deciliter for blood urea nitrogen and units per liter for all other biochemical markers and are means ± SDs from two independent assays. Reference values (CECAL/Fiocruz) are as follows: blood urea nitrogen (BUN), up to 29 mg/dl; alanine aminotransferase (ALT), up to 132 U/liter; aspartate transaminase (AST), up to 247 U/liter; creatine kinase (CK), up to 1,070 U/liter. P was <0.05 by ANOVA for all samples. ND, not determined due to animal death at the higher dose.
b
Results are from one representative assay.