TABLE 2.
The impact of each covariate
| Analysis method and covariate groupa | Nameb | Δ in objective function |
|---|---|---|
| Univariate analysis (covariate added) | ||
| CL | SCR | −50.49 |
| GA | −69.07 | |
| PNA | −111.31 | |
| PMA | −93.51 | |
| PNA-NL | −122.87 | |
| PMA-NL | −146.78 | |
| Gender | −3.10 | |
| Vss | SCR | −2.62 |
| GA | −11.56 | |
| PNA | −0.14 | |
| PMA | −0.72 | |
| Gender | −0.00 | |
| Multivariate analysis (covariate removed) | ||
| CL | SCR | 17.06 |
| PMA-NL | 110.90 | |
| Vss | GA | 9.43 |
a
CL, clearance; Vss, volume of steady state.
b
SCR, serum creatinine; GA, gestational age; PNA, postnatal age; PMA, postmenstrual age; NL, nonlinear.