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Final population pharmacokinetic model
| Modela | Estimated levelb |
|---|---|
| CL (liters/h) | 0.395 × [−0.09 + 1.09 × {1 − exp(−0.00958 × PMA)}] × wt0.75 × (SCR/0.6)−0.392 |
| Vss (liters) | 0.406 × wt × (GA/30)−0.548 |
| Intersubject variability (%) | |
| CL | 31.8 |
| Vss | 22.2 |
| Residual variability (%) | 66.3 |
CL, clearance; Vss, volume distribution at steady state.
PMA, postmenstrual age (weeks); wt, weight (kg); GA, gestational age; SCR; serum creatinine.
