TABLE 4.

Pharmacokinetic parameters by different age group

Parametera	Mean value (±SD) by patient groupb
	All ages	Pediatric	Term	Preterm
No. of patients	91	47	12	32
CL (ml/min/kg)	1.86 ± 1.12	2.59 ± 1.10	1.24 ± 0.30	1.03 ± 0.40
Vss (liters/kg)	0.38 ± 0.08	0.37 ± 0.07	0.35 ± 0.03	0.40 ± 0.10
t1/2(β) (h)	3.53 ± 2.06	2.45 ± 1.77	3.59 ± 0.61	5.09 ± 1.80
Css min (μg/ml)b	16.07 ± 18.77	6.38 ± 13.40	15.42 ± 6.72	30.56 ± 19.52
Css max (μg/ml)b	181.04 ± 27.50	171.89 ± 23.47	192.92 ± 19.64	190.02 ± 31.25

^aCL, clearance; Vss, volume of distribution at steady state; Css min, minimum concentration at steady state; Css max, maximum concentration at steady state; GA, gestational age; t_1/2(β), elimination phase half-life.

^bPediatric, age of ≥30 days; term, age of <30 days and GA of ≥36 weeks; preterm, age of <30 days and GA of <36 weeks. Actual milligram doses that patients received were used for estimation. Dosing intervals were set as q12h for estimation. Actual milligram doses that patients received were as follows: all patients, 48.8 ± 4.7 mg/kg/dose; pediatric patients, 48.2 ± 5.9 mg/kg/dose; term patients, 49.9 ± 0.2 mg/kg/dose; preterm patients, 49.2 ± 3.3 mg/kg/dose.