TABLE 5.
Bootstrap validation of the population pharmacokinetic parameters
| Model parameterb | Final estimate ± SE | Bootstrap validation (n = 1,000)a |
|---|---|---|
| θ1 (liters/h/kg0.75) | 0.395 ± 0.049 | 0.396 (0.315 to 0.550) |
| θ2 (liters/kg) | 0.406 ± 0.023 | 0.404 (0.361 to 0.451) |
| θ3 | 0.460 ± 0.020 | 0.452 (0.002 to 0.487) |
| θ4 (liters/h/kg0.75) | 0.575 ± 0.049 | 0.580 (0.488 to 2.570) |
| θ5 | 0.705 ± 0.039 | 0.705 (0.598 to 0.785) |
| θ6 | 1.09 ± 0.087 | 1.09 (0.945 to 1.320) |
| θ7 | 0.010 ± 0.003 | 0.010 (0.004 to 0.016) |
| θ8 | −0.392 ± 0.101 | −0.396 (−0.620 to −0.191) |
| θ9 | −0.548 ± 0.221 | −0.555 (−1.01 to −0.106) |
| %ωCL | 31.80 ± 12.90 | 30.6 (25.1 to 35.8) |
| %ωVss | 22.20 ± 12.60 | 21.1 (14.1 to 28.7) |
| %σ | 66.30 ± 37.30 | 66.1 (48.6 to 98.8) |
a
Values are medians (2.5th to 97.5th percentile). The success rate was 86.9%.
b
θ1, TVCL after maturation; θ2, TVVss; θ3, ratio of TVV/TVVss; θ4, typical value of intercompartmental clearance; θ5, fraction of additive and proportional error; θ6, fraction of mature CL at birth; θ7, rate constant for CL gain; θ8, exponent for serum creatinine for CL; θ9, exponent for gestational age for Vss. CL, clearance; Vss, steady-state volume of distribution.