TABLE 5.
Cox proportional hazards regression models for renal failure in subgroupsb
| Variable | ICU, n = 281; CMS = 59/PMB = 222 |
Non-ICU, n = 210; CMS = 22/PMB = 188 |
GFR of ≥60 ml/min, n = 245; CMS = 53/PMB = 192 |
GFR of <60 ml/min, n = 246; CMS = 28/PMB = 218 |
High doses of polymyxina, n = 353; CMS = 58/PMB = 295 |
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|---|---|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
| CMS | 4.27 (2.36–7.74) | <0.001 | 2.79 (0.89–8.81) | 0.08 | 3.95 (1.98–7.89) | <0.001 | 2.53 (1.15–5.57) | 0.02 | 2.57 (1.48–4.48) | 0.001 |
| ICU | 1.41 (0.69–2.85) | 0.34 | 2.89 (1.31–6.36) | 0.01 | 1.73 (1.00–3.01) | 0.051 | ||||
| Weight (kg) | 1.03 (1.02–1.05) | <0.001 | 1.01 (0.98–1.05) | 0.50 | 1.01 (0.99–1.03) | 0.26 | 1.04 (1.02–1.06) | <0.001 | 1.02 (1.01–1.04) | 0.003 |
| Age (yr) | 1.02 (1.00–1.03) | 0.042 | 1.02 (0.99–1.04) | 0.21 | 1.03 (1.02–1.05) | <0.001 | 0.98 (0.96–1.01) | 0.19 | 1.02 (1.00–1.04) | 0.01 |
| Abdominal infection | 2.84 (1.29–6.26) | 0.01 | 2.96 (0.99–8.90) | 0.53 | 4.12 (1.71–9.95) | 0.01 | 1.02 (0.37–2.80) | 0.98 | 2.63 (1.39–4.95) | 0.003 |
| Bacteremia | 1.04 (0.49–2.23) | 0.91 | 4.08 (1.52–10.9) | 0.01 | 1.45 (0.60–3.48) | 0.41 | 2.22 (0.97–5.08) | 0.06 | 1.97 (1.02–3.79) | 0.04 |
| APACHE II | 1.03 (0.96–1.05) | 0.88 | ||||||||
a
High doses: CMS, ≥300 mg/day; PMB, ≥150 mg/day. Including only PMB patients who received doses ≥200 mg/day, CMS remained a significant risk factor for renal failure (HR, 2.28; 95% CI, 1.13 to 4.59; P = 0.021).
b
Blank cells, not performed or not applicable.