Table 2.
Genes with evidence for differential regulation post-LPS in placebo and n-3 PUFA
| Placebo | n-3 PUFA | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Gene | Gene Name | FPKM Pre-LPS |
FPKM Post-LPS |
Adjusted P Value |
FPKM Pre-LPS |
FPKM Post-LPS |
Adjusted P Value |
Functional Enrichment (pathway analysis) |
Additional known relevant functions |
| Significantly down-regulated post-LPS in placebo, up in n-3 PUFA | |||||||||
| CCL18 | chemokine (C-C motif) ligand 18 | 9.8 | 3.9 | 0.009 | 6.2 | 13.3 | 0.042 | Immune Response; Secreted Protein; Signaling Protein | immunosuppression |
| CCL3 | chemokine (C-C motif) ligand 3 | 6.7 | 1.7 | 0.002 | 2.3 | 3.4 | 0.866 | Immune Response; Secreted Protein; Signaling Protein | |
| RGS2 | regulator of G-protein signaling 2, 24kDa | 11.7 | 6.6 | 0.011 | 8.9 | 16.9 | 0.010 | adipocyte differentiation | |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 2.8 | 0.9 | 0.002 | 1.0 | 2.2 | 0.020 | Secreted; Signaling Protein | associated with lipid rafts |
| APLN | apelin | 1.0 | 0.4 | 0.026 | 0.8 | 1.3 | 0.638 | Immune Response; Secreted Protein; Signaling Protein | blood pressure, angiogenesis |
| FCGR3A | Fc fragment of IgG, low affinity IIIa, receptor (CD16a) | 9.4 | 5.5 | 0.019 | 6.0 | 6.8 | 0.999 | Immune Response; Secreted Protein; Signaling Protein | |
| FCN1 | ficolin (collagen/fibrinogen domain containing) 1 | 5.7 | 2.1 | 0.002 | 2.2 | 4.6 | 0.134 | Immune Response; Secreted Protein; Signaling Protein | |
| HES1 | hes family bHLH transcription factor 1 | 17.3 | 7.0 | 0.002 | 12.9 | 12.4 | 0.999 | ||
| IL1RN | interleukin 1 receptor antagonist | 11.0 | 5.1 | 0.009 | 5.5 | 6.6 | 0.999 | Immune Response; Secreted Protein; Signaling Protein | |
| IL7R | interleukin 7 receptor | 1.1 | 0.5 | 0.042 | 0.6 | 0.7 | 0.999 | Immune Response; Secreted Protein; Signaling Protein | |
| IL8 | interleukin 8 | 1.0 | 0.2 | 0.032 | 0.4 | 0.8 | 0.399 | Immune Response; Secreted Protein; Signaling Protein | |
| LCP1 | lymphocyte cytosolic protein 1 (L-plastin) | 26.2 | 16.9 | 0.010 | 21.3 | 22.0 | 0.999 | Immune Response | |
| TREM1 | triggering receptor expressed on myeloid cells 1 | 1.2 | 0.4 | 0.037 | 0.3 | 0.7 | 0.417 | Immune Response; Secreted Protein; Signaling Protein | |
| Significantly up-regulated post-LPS in placebo down in n-3 PUFA | |||||||||
| FADS1 | fatty acid desaturase 1 | 20.9 | 40.5 | 0.023 | 26.9 | 27.8 | 0.999 | biosynthesis of unsaturated fatty acids | |
| PPARG | peroxisome proliferator-activated receptor gamma | 172.2 | 378.4 | 0.002 | 212.6 | 294.7 | 0.176 | Immune Response | adipose n-3 PUFA receptor |
| Significantly up-regulated post-LPS in n-3 PUFA, down in placebo | |||||||||
| FCGR3B | Fc fragment of IgG, low affinity IIIb, receptor (CD16b) | 1.2 | 0.9 | 0.975 | 0.4 | 5.4 | 0.003 | Immune Response; Secreted Protein; Signaling Protein | |
| IER5L | Immediate Early Response 5-Like | 3.4 | 2.9 | 0.986 | 2.6 | 5.0 | 0.003 | early cellular response | |
| PTGDS | prostaglandin D2 synthase | 13.9 | 16.1 | 1.000 | 18.2 | 32.2 | 0.012 | Secreted; Signaling Protein | prostaglandin synthesis |