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Proposed mechanisms for the protective effects of dietary walnuts against hepatic fat accumulation in HFD-fed mice. Walnut supplementation activates AMPK with decreased FAS protein level in the livers of HFD-fed mice. In addition, dietary walnuts decrease macrophage infiltration and apoptosis in the adipose tissues of HFD-fed mice, contributing to decreased levels of circulating cytokines and thus preventing diet-induced hepatic fat accumulation.
