Table 3.
Demographic information | QTc (msec) | Quetiapine dose | Other QTc prolonging medications | Intervention | Outcome | |
---|---|---|---|---|---|---|
Patient 1 | Toddler with respiratory failure in the setting of a viral infection | 466 | 4 mg/kg/day | None | None | Repeat QTc 382 |
Patient 2 | School-age child with history of bone marrow transplant, and severe hypoxemic respiratory failure | 548 | 3.3 mg/kg/day | Ondansetron | None | Repeat QTc 498. Patient died prior to next assessment after parents requested withdrawal of support. |
Patient 3 | Adolescent with respiratory failure in setting of asthma exacerbation | 456 | 6.3 mg/kg/day | None | Reduction of dose | Repeat QTc 437 on weaning dose of 4.5mg/kg/day |