Table 3.
Patient Factors and Discontinuation
| Covariate | Univariate analysis (N = 2,840) |
Multivariable analysis (n = 2,628) |
||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Age, per 1-year older | 1.04 (0.99, 1.10) | 0.9 | 0.98 (0.93, 1.05) | 0.6 |
| Race | ||||
| White | 1.00 (reference) | 1.00 (reference) | ||
| Black | 1.13 (0.96, 1.32) | 0.2 | 1.10 (0.92, 1.33) | 0.3 |
| Other | 1.02 (0.69, 1.51) | 0.9 | 1.07 (0.70, 1.64) | 0.8 |
| Ethnicity | ||||
| Non-Hispanic | 1.00 (reference) | 1.00 (reference) | ||
| Hispanic | 1.04 (0.74, 1.44) | 0.8 | 1.11 (0.78, 1.57) | 0.6 |
| Sex | ||||
| Women | 1.00 (reference) | 1.00 (reference) | ||
| Men | 0.90 (0.78, 1.05) | 0.2 | 0.97 (0.74, 1.02) | 0.09 |
| Primary ESRD cause | ||||
| Diabetes | 1.00 (reference) | 1.00 (reference) | ||
| Hypertension | 0.95 (0.78, 1.15) | 0.6 | 1.25 (0.96, 1.62) | 0.09 |
| Glomerulonephritis | 0.73 (0.59, 0.90) | 0.004 | 0.91 (0.68, 1.22) | 0.5 |
| Cystic | 0.63 (0.45, 0.89) | 0.009 | 0.88 (0.59, 1.31) | 0.5 |
| Other | 0.82 (0.66, 1.01) | 0.06 | 0.99 (0.76, 1.30) | 0.9 |
| ESRD duration, per 1-year greater | 0.99 (0.98, 1.01) | 0.1 | 0.99 (0.98, 1.01) | 0.8 |
| Median household income | ||||
| Quartile 1 | 1.00 (reference) | 1.00 (reference) | ||
| Quartile 2 | 0.99 (0.81, 1.22) | 0.9 | 0.96 (0.77, 1.20) | 0.7 |
| Quartile 3 | 1.01 (0.83, 1.25) | 0.9 | 0.99 (0.80, 1.25) | 0.9 |
| Quartile 4 | 1.00 (0.81, 1.23) | 0.9 | 1.02 (0.81, 1.29) | 0.9 |
| Current Smoking/Alcohol/Drug use | 1.40 (0.80, 1.86) | 0.04 | 1.34 (1.01, 1.78) | 0.04 |
| Comorbid Conditions | ||||
| Diabetes | 1.35 (0.78, 1.16) | <0.001 | 1.34 (1.07, 1.68) | 0.01 |
| Inability to ambulate or transfer | 1.22 (1.16, 1.56) | 0.4 | 1.10 (0.71, 1.69) | 0.7 |
| No. of other comorbid conditions* | ||||
| 0 | 1.00 (reference) | 1.00 (reference) | ||
| 1 | 0.84 (0.66, 1.06) | 0.1 | 0.84 (0.65, 1.08) | 0.2 |
| ≥2 | 0.97 (0.76, 1.24) | 0.8 | 0.88 (0.66, 1.16) | 0.4 |
| Listed for transplant at HHD initiation | 0.69 (0.58, 0.81) | <0.001 | 0.73 (0.61, 0.87) | 0.001 |
| Rural residence: RUCA score ≥7 | 0.73 (0.57, 0.95) | 0.02 | 0.78 (0.59, 1.02) | 0.08 |
*
Other comorbid conditions includes hypertension, peripheral vascular disease, heart disease, cerebrovascular disease, congestive heart failure, cancer, and chronic obstructive pulmonary disease
Abbreviations: CI, confidence interval: HHD, home hemodialysis; HR, hazard ratio; ESRD, End Stage Renal Disease; RUCA, rural-urban commuting area