Table 4.
Associations between Lp-PLA2 and incident low ankle-brachial index*
| Incident Cases of Low ABI | Model 1† | Model 2‡ | |
|---|---|---|---|
|
| |||
| OR (95% CI) | OR (95% CI) | ||
| Lp-PLA2 Mass, ng/ml (n=3537) | |||
| 1st quartile (57.5–255.1) | 51 | 1.0 (Referent) | 1.0 (Referent) |
| 2nd quartile (255.1–325.2) | 41 | 0.94 (0.61, 1.46) | 0.91 (0.58, 1.44) |
| 3rd quartile (325.3–402.3) | 53 | 1.42 (0.93, 2.17) | 1.34 (0.86, 2.08) |
| 4th quartile (402.3–944.3) | 67 | 1.69 (1.12, 2.56) | 1.49 (0.96, 2.30) |
|
| |||
| Per SD (117.4) | 1.22 (1.07, 1.40) | 1.16 (1.00, 1.33) | |
| p-value (linear) | .004 | .046 | |
|
| |||
| Lp-PLA2 Activity, nmol/min/ml (n=3537) | |||
| 1st quartile (8.6–30.2) | 57 | 1.0 (Referent) | 1.0 (Referent) |
| 2nd quartile (30.2–37.4) | 37 | 0.75 (0.48, 1.17) | 0.67 (0.42, 1.07) |
| 3rd quartile (37.4–46.3) | 49 | 1.15 (0.76, 1.76) | 0.96 (0.61, 1.53) |
| 4th quartile (46.3–146.7) | 69 | 1.79 (1.18, 2.71) | 1.45 (0.89, 2.35) |
|
| |||
| Per SD (13.0) | 1.32 (1.16, 1.52) | 1.28 (1.09, 1.50) | |
| p-value (linear) | <.001 | .002 | |
*
Results of multivariable logistic regression models are shown for both Lp-PLA2 mass and activity by quartiles of the distribution, with each Lp-PLA2 quartile compared with the 1st quartile (referent quartile), and per standard deviation increment
†
Model 1 adjusted for age (years), male sex, black, clinic site and time between ABI measures
‡
Model 2 adjusted for Model 1 + cigarette smoking, cardiovascular disease, diabetes, total cholesterol, HDL-c, hypertension, statin use, physical activity, CRP, and eGFR