Figure 5.
MK-801 selectively impairs source memory, while small molecule PSD95-nNOS inhibitors IC87201 and ZL006 spared both spatial working memory and source memory. A,C. High spatial working memory performance is represented by a high revisit rate to previously unvisited chow locations. Treatment with the NMDAR antagonist MK-801, and PSD95-nNOS small molecule inhibitors IC87201 and ZL006 did not impair spatial working memory. B,D. Positive source memory scores document that rats preferentially revisit the chocolate location that is about to replenish while avoiding the non-replenishing chocolate location. *p < 0.05, **p < 0.01. Data are shown as means + SEM.