Dependence of FORCE-ALTM (column 1), CA-ALTM (column 2), and APV-ALTM (column 3) on the level of mechanical remodeling for pacing CL=600 ms and SL=2.1 μm for the strongly coupled model (solid lines). Dashed line in the FORCE-ALTM refers to the weakly coupled model. Heart-failure remodeling mechanical parameters perm50 (row 1), koffH (row 2), and kon (row 3), are displayed as a percent of their normal values.