Table 1.
Baseline demographics and ocular characteristics by group and race*
| Healthy | Progressing glaucoma | P** value |
Stable Glaucoma |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| By Subject | African Descent n=88 (53%) |
European Descent n=69 (47%) |
Total n=157 |
P | African Descent n=24 (35%) |
European Descent n=43 (65%) |
Total n=67 | P | 0.008 | n = 35 |
| Mean Age at baseline (years) |
48.4 ± 13.3 | 49.5 ± 15.3 | 48.9 ± 14.2 | 0.474 | 54.5 ± 13.2 | 62.3 ± 10.4 | 59.5 ± 12.0 | 0.014 | <.001 | 71.8 ± 9.2 |
| Gender, Female (%) | 53 (60%) | 43 (62%) | 96 (61%) | 0.869 | 15 (63%) | 22 (51%) | 37 (55%) | 0.447 | 0.458 | 14 (40%) |
| By Eye |
n=169 (57%) |
n=127 (43%) |
n=296 |
n=25 (34%) |
n=48 (66%) |
n=73 | 0.002 | n=63 | ||
| Baseline IOP (mmHg) | 15.1 ±2.7 | 15.5±2.7 | 15.3 ± 2.7 | 0.172 | 16.7 ± 4.3 | 18.5 ± 8.0 | 17.9 ± 7.0 | 0.510 | 0.004 | NA |
| Mean IOP during follow- up (mmHg) |
15.2 ± 2.5 | 15.3 ±2.3 | 15.2 ± 2.4 | 0.825 | 15.8 ±3.7 | 15.2 ± 4.2 | 15.5 ± 3.8 | 0.601 | 0.738 | 14.2 ± 4.6 |
| CCT (µm) | 530 ± 33 | 555 ± 37 | 541 ± 37 | <.001 | 525 ± 45 | 544 ±42 | 538 ± 44 | 0.101 | 0.819 | 550 ± 41 |
| Disc area (mm2) | 2.09 ± 0.5 | 1.9 ± 0.4 | 2.01 ± 0.4 | <.001 | 2.19 ± 0.4 | 1.97 ±0.4 | 2.04 ± 0.4 | 0.039 | 0.480 | 2.05 ± 0.5 |
| Baseline MD (dB) | −0.59 ±1.2 | −0.11 ± 1.0 | −0.38 ± 1.2 | <.001 | −4.49 ± 5.3 | −3.5 ± 4.4 | −3.85 ± 4.7 | 0.736 | <.001 | −7.3 ± 8.6 |
| Median No. of HRT visits, (Interquartile range) |
4 (3–7) |
4 (3–5) |
4 (3–6) |
0.006 | 11 (9–12) |
10.5 (9–12) |
11 (9–12) |
0.898 | <.001 | 5 (5–5) |
| Median Follow up (years) (Interquartile range) |
5.5 (3.1–7.3) |
4.9 (3.0–7.4) |
5.0 (2.0–7.4) |
0.470 | 7.8 (7–8.1) |
9.1 (7.8–11.4) |
8.3 (7.5–9.9) |
<.001 | <.001 | 4 weeks (4–4) |
| Rate VFI of change over time (%/year) |
−0.02±0.02 P=0.334 |
−0.001±0.03 P=0.960 |
−0.01±0.02 P=0.445 |
0.321 | −0.61±0.21 P=0.003 |
−0.64±0.13 P<0.001 |
−0.63±0.11 P<0.001 |
0.478 | <.001 | 0.09 ±8.1 P=0.740 |
| Rate of MD change over time (dB/year) |
0.03±0.02 P=0.614 |
0.04±0.01 P=0.400 |
−0.04±0.02 P=0.120 |
0.512 | −0.17±0.08 P=0.042 |
−0.22±0.05 P<0.001 |
−0.20±0.04 P<0.001 |
0.036 | <.001 | −0.03±3.3 P=0.960 |
*
Data are presented as mean±SD unless otherwise indicated
**
P-value representing the difference between the healthy and progressing glaucoma groups
Abbreviations: AD, African Descent; ED, European Descent; IOP, Intraocular Pressure; CCT, Central Corneal Thickness; MD, Mean Deviation; HRT, Heidelberg Retinal Tomograph.