Table 2.
Characteristics of Four GERD Phenotypes from pH-Impedance Monitoring on PPI
| Strong Reflux Evidence n=6 |
Good Reflux Evidence n=17 |
Reflux Hypersensitivity n=24 |
Equivocal or No Reflux Evidence n=46 |
p values† | |
|---|---|---|---|---|---|
| Mean age (yr) | 47.2±2.5 | 51.4±2.5 | 58.5±2.0 | 53.0±2.1 | 0.104 |
| Gender (F) | 5 (83.3%) | 12 (70.6%) | 19 (79.2%) | 33 (71.7%) | 0.842 |
| Race (Caucasian) | 6 (100%) | 13 (76.5%) | 22 (91.7%) | 36 (78.3%) | 0.616 |
| Typical symptoms* | 5 (83.3%) | 10 (58.8%) | 15 (62.5%) | 24 (52.2%) | 0.489 |
| Duration of follow-up (mo) | 32.3±3.8 | 42.2±3.5 | 44.1±4.3 | 42.3±2.6 | 0.553 |
| Surgical Treatment | 4 (66.7%) | 8 (47.1%) | 7 (29.2%) | 5 (10.9%) | 0.002 |
| DSI | |||||
| Baseline | 14.0±2.0 | 8.3±1.2 | 9.4±1.2 | 7.6±0.9 | 0.061 |
| Change** | 7.2±4.0 | 4.5±1.5 | 6.2±1.3 | 3.5±0.9 | 0.306 |
| Follow-up | 6.8±3.2 | 3.8±1.1 | 3.2±1.0 | 4.1±0.7 | 0.491 |
| ≥50% Improvement | 3 (50.0%) | 10 (62.5%) | 17 (77.3%) | 26 (61.9%) | 0.518 |
| GSS | |||||
| Baseline | 74.3±8.7 | 66.1±5.3 | 61.9±6.2 | 58.1±3.9 | 0.421 |
| Change** | 40.2±14.5 | 38.7±8.9 | 36.0±7.7 | 19.4±3.7 | 0.057 |
| Follow-up | 34.2±11.6 | 27.4±6.5 | 23.0±6.0 | 37.7±4.2 | 0.194 |
| ≥50% Improvement | 3 (50.0%) | 12 (70.6%) | 11 (55.0%) | 13 (29.5%) | 0.022 |
PPI: proton pump inhibitor; DSI: dominant symptom intensity; GSS: global symptom severity
*
heartburn, acid regurgitation
**
between baseline and follow-up assessments
†
ANOVA for continuous variables, chi-square for categorical variables