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. Author manuscript; available in PMC: 2017 Apr 15.
Published in final edited form as: Bioorg Med Chem Lett. 2016 Mar 2;26(8):2030–2034. doi: 10.1016/j.bmcl.2016.02.085

Scheme 2.

Scheme 2

Synthetic pathways for compounds 6a–e

Reagents and conditions: (i) NaOCH3, CH3OH, room temp. 3 h; (ii) dimethyloxalate, CH3OH, NaOCH3 reflux, 12 h; (iii) phenylhydrazine, EtOH, AcOH, reflux 18 h.