Table 1.

IC₅₀ Values for New Triazine Analogues.

Name of Compound	Formula Weight	OV 90	A2780	MCF-7	MDA-MB231	A549	H1299	HT-29
TZ9	366.3	60	7.8	5	4.6	7.2	45	8.3
3a	245.24	75	7.3	5.9	2.6	7.8	65	3.3
3b	275.27	80	14.7	6.2	7.6	5.2	65	5.4
3c	259.27	60	5.5	16	12.7	9.3	40	4.5
3d	275.27	90	5.6	11.8	15.7	7.5	50	8.6
3e	279.69	85	36.6	8.8	24.6	7.5	30	4.6
6a	397.43	8	7.1	6	2.5	14.6	11	9.5
6b	457.48	12	6.3	7.2	4.2	10.8	5	5.8
6c	425.49	5	3.6	4.2	3.5	11.6	22	5.2
6d	457.48	10	5	7.2	3.9	6.9	26	8.9
6e	466.32	60	8.2	4.2	3.5	7.8	15	4.1

As described in the methods, the MTS assay was used to evaluate cell survival in the presence of each new triazine analogue in the range of 0 to 125 μM concentrations. For each cell line, the MTS assays were performed at least three independent experiments and each time in triplicates. The results presented in the table are average values from multiple experiments. The IC₅₀ values were calculated from the data of % survival vs. drug concentration using Microsoft Excel 2010.