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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Arch Toxicol. 2015 Sep 24;90(9):2187–2200. doi: 10.1007/s00204-015-1600-z

Fig. 4. TMP prevented arsenic-triggered activations of the intrinsic apoptotic pathway and ERK pathway in HK-2 cells.

Fig. 4

(a) As treatment (24 h) increased protein levels of pro-apoptotic Bax and pro-caspase9 expressions and decreased levels of anti-apoptotic Bcl-xl, and PARP cleavage, while TMP (50 μM and 100 μM) pretreatment prevented As-triggered the intrinsic apoptotic pathway activation. (b) As-induced ERK activation was verified by increased level of phospho-Thr202/Tyr204 ERK (p-ERK) expression, which was inhibited by TMP pretreatment. β-actin was used as loading control. Values are mean ± SD (n=3).