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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: Biochim Biophys Acta. 2015 Sep 25;1862(5):952–956. doi: 10.1016/j.bbadis.2015.09.013

Figure 4.

Figure 4

Typical cognitive decline trajectories that may be expected in pure vs. multi-etiology dementias as a function of time. Panel A illustrates trajectories when the evolution of CVP and ADP are nearly at the same time. Panel B illustrates trajectories when CVP starts at a later time after the onset of ADP. Panel C illustrates trajectory where the event of a single strategic infarct (pure CVP) is followed shortly by the onset of ADP. The threshold shown in the figure indicates the cognitive threshold for dementia detection.