Table 2.
Th17 cells, serum IL-17, and IL-23 levels with respect to disease activity parameters and immunosuppressants.
| Activity measured by NIH criteria | |||
|---|---|---|---|
| Active (n = 13) | Inactive (n = 17) | p value (Mann-Whitney) | |
| Th17 cells (%) | 2.1 (1.4–3) | 2.05 (1.6–4.3) (n = 16∗) | 0.55 |
| IL-17A (pg/mL) | 7.4 (4.7–9) | 5.3 (4.4–8.5) | 0.56 |
| IL-23 (pg/mL) | 14.9 (14.9–17.7) | 15 (14.9–30.5) | 0.07 |
|
| |||
| Activity measured by ITAS2010 ≥ 4 | |||
| Active (n = 12) | Inactive (n = 18) | p value (Mann-Whitney) | |
|
| |||
| Th17 cells (%) | 2.2 (1.4–3.1) | 1.9 (1.6–4.2) (n = 17∗) | 0.80 |
| IL-17A (pg/mL) | 7.7 (4.7–9.2) | 5.4 (4.4–8.6) | 0.54 |
| IL-23 (pg/mL) | 14.9 (14.9–19) | 15 (14.9–28.7) | 0.13 |
|
| |||
| Data with respect to immunosuppressants | |||
| Not on immunosuppressants (n = 13) | On immunosuppressants∗∗ (n = 17) | p value (Mann-Whitney) | |
|
| |||
| Th17 cells (%) | 2 (1.3–2.8) | 2.3 (1.6–3.8) (n = 16∗) | 0.30 |
| IL-17A (pg/mL) | 6.5 (4.7–9) | 6.1 (4.4–8.6) | 0.85 |
| IL-23 (pg/mL) | 14.9 (14.9–20.6) | 15 (14.9–26.6) | 0.36 |
Values represented as median with interquartile range in brackets.
∗Th17 cell population could not be studied in one patient due to technical difficulties.
∗∗14 patients were on prednisolone, 11 on oral methotrexate, and 3 on azathioprine.