Table 1.
Patient characteristics at enrollment for the N=380 participants with indeterminate diagnosis (IND), overall and by identified latent subgroup index.
| characteristics | All N=380 |
Subgroup1 N=59 (15.5%) |
Subgroup2 N=57 (15%) |
Subgroup3 N=48 (12.6%) |
Subgroup4 N=130 (34.2%) |
Subgroup5 N=86 (22.6%) |
pA |
|---|---|---|---|---|---|---|---|
| Age (yrs)** | N=380 3.5 (1.0,9.2) |
N=59 1.7 (0.9,6.3) |
N=57 4.2 (1.6,11.0) |
N=48 3.1 (0.5,9.4) |
N=130 3.3 (0.6,9.3) |
N=86 5.7 (1.5,10.0) |
0.1 |
|
| |||||||
| INR** | N=303 2.7 (2.1,3.9) |
N=46 2.3 (1.8,3.7) |
N=47 2.2 (1.8,2.7) |
N=41 3.6 (2.7,7.0) |
N=95 2.6 (2.1,3.5) |
N=74 3.1 (2.3,5.1) |
N/A |
|
| |||||||
| Total bilirubin** | N=312 13.7 (5.1,19.8) |
N=51 1.8 (0.9,2.5) |
N=51 8.4 (5.4,11.4) |
N=41 19.1 (9.8,25.4) |
N=100 17.6 (12.5,20.2) |
N=69 16.5 (13.4, 23.6) |
N/A |
|
| |||||||
| HE* | N=367 | N=56 | N=54 | N=47 | N=126 | N=84 | N/A |
| None | 169(46%) | 21(38%) | 28(52%) | 14(30%) | 58(46%) | 48(57%) | |
| I–II | 157(43%) | 28(50%) | 15(28%) | 25(53%) | 61(48%) | 28(33%) | |
| III–IV | 41(11%) | 7(13%) | 11(20%) | 8(17%) | 7(6%) | 8(10%) | |
|
| |||||||
| Jaundice* | N=150 | N=35 | N=20 | N=15 | N=48 | N=32 | <.001 |
| Yes | 102(68%) | 5(14%) | 14(70%) | 9(60%) | 45(94%) | 29(91%) | |
|
| |||||||
| Ascites* | N=378 | N=59 | N=57 | N=48 | N=128 | N=86 | 0.002 |
| Yes | 71(19%) | 3(5%) | 5(9%) | 11(23%) | 33(26%) | 19(22%) | |
|
| |||||||
| ALT (U/L)** | N=297 1897 (793,3156) |
N=49 3615 (2051,6545) |
N=46 2209 (879,3278) |
N=41 1390 (896,3893) |
N=95 1350 (461,2372) |
N=66 1992 (1074,2980) |
<.001 |
|
| |||||||
| Albumin** | N=323 2.9 (2.5,3.2) |
N=55 2.8 (2.3,3.3) |
N=51 3.0 (2.6,3.2) |
N=42 2.8 (2.6,3.2) |
N=103 2.7 (2.4,3.1) |
N=72 2.9 (2.6,3.4) |
0.1 |
*
summarized by freq (%);
**
summarized by median (25th, and 75th percentiles).
A
The p-values reflect the difference across the 5 subgroups. Statistical tests were not conducted for the three elements (INR, total bilirubin and HE) used for subgroup classification. Statistical tests were conducted for Age, Jaundice, Ascites, ALT and Albumin, which were not used for subgroup classification in the GMM model.