Table 4. Changes in raw values of sex hormones over time following treatment with infliximab.
Median and intraquartile ranges are shown. Data reflect all participants included in the mixed model analysis, including those who were missing data at individual time points. Paired t-tests were performed for those with levels at either baseline and 10-week or baseline and 1-year, accounting for instances where the median level for a group decreases but the paired t-test reveals an increase in hormone level over the time interval.
| Tanner stage (number, percent) | Testosterone (ng/mL) | LH (mIU/mL) | FSH (mIU/mL) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline | 1-year | Baseline n=41 | 10-week# n=40 | 1-year# n=35 | Baseline n=37 | 10-week# n=36 | 1-year# n=35 | Baseline n=34 | 10-week# n=34 | 1-year# n=31 | |
| Males | |||||||||||
| Tanner 2 | 12 (23.5) | 5 (11) | 4.5 (4.0, 7.5) | 15.5* (6.5, 55.5) | 76 ** (12, 142) | 0.3 (0.2, 0.5) | 1.05 (0.7, 1.6) | 1.7 * (0.7, 2.1) | 1.1 (0.3, 1.2) | 1.8 (1.3, 2.7) | 1.5 (0.8, 3.1) |
| Tanner 3 | 10 (19.6) | 9 (19.5) | 71 (4, 189) | 139.5 (31–198) | 100 (68, 230) | 0.9 (0.2, 6) | 2.3 (0.8, 5.3) | 4.0 (0.8, 5.0) | 3.6 (0.9, 7.1) | 3.4 (1.6, 7.2) | 2.6 (1.2, 2.9) |
| Tanner 4 | 11 (21.6) | 6 (13.0) | 246 (155, 595) | 402 (276, 630) | 409 (386, 461) | 3.15 (1.9, 4.0) | 2.7 (2.0, 3.7) | 3.0 (2.6, 4.1) | 4.2 (2.1, 8.6) | 2.6 (1.7, 5.9) | 4.2 (2.1, 4.5) |
| Tanner 5 | 9 (17.6) | 17 (37.0) | 442 (143, 522) | 556 (734, 523) | 520.5 (378, 647) | 3.9 (2.0, 5.0) | 4.8 (4.0, 7.6) | 3.4 (2.0, 5.7) | 2.8 (1.2, 6.7) | 5.9 (1.8, 7.7) | 4.5 (1.2, 5.4) |
| Females | Estradiol (pg/mL) | LH (mIU/mL) | FSH (mIU/mL) | ||||||||
| n=22 | n=25 | n=22 | n=18 | n=21 | n=20 | n=18 | n=21 | n=18 | |||
| Tanner 2 | 5 (14.7) | 3 (11.1) | 2.5 (2.0, 6.0) | 38 (6, 41) | 48 (11, 80) | 1.0 (0.1, 1.8) | 2.0 (1.1, 4.0) | 3.1 (0.3, 8.7) | 1.45 (0.2, 2.7) | 2.2 (0.9, 4.2) | 3.8 (1.4, 5.1) |
| Tanner 3 | 8 (23.5) | 4 (14.8) | 21 (2, 59.5) | 21 (15, 25) | 45 (30, 56) | 4.5 (1.1, 14.5) | 4.1 (3.6, 6.8) | 6.0 (4.7, 9.5) | 3.9 (1.9, 6.0) | 4.7 (3.9, 5.5) | 5.2 (4.1, 6.2) |
| Tanner 4 | 11 (32.4) | 9 (33.3) | 38 (6.5, 74.5) | 34 * (15, 71) | 61 (13, 129) | 1.75 (0.1, 4.0) | 6.7 (3.6, 8.7) | 3.2 (1.2, 4.3) | 1.45 (0.2, 6.0) | 3.2 (2.8, 4.3) | 2.9 (1.1, 4.0) |
| Tanner 5 | 6 (17.6) | 10 (37.0) | 49.5 (28.0, 129) | 70.5 (25.5, 143.0) | 30 (7, 67) | 5.7 (3.3, 19.4) | 4.8 (1.5, 14.6) | 5.1 (4.1, 5.6) | 4.5 (2.9, 4.7) | 4.6 (4.0, 5.3) | 5.7 * (4.6, 5.8) |
#
Values according to the participant’s baseline Tanner stage.
Comparisons: Higher than baseline value using a paired t-test on log-transformed values:
*
p<0.05;
**
p<0.01.