Fig. 2.
Cross-sectional analysis of the prostatectomy specimen of a patient who had Gleason 6 tumor at study entry, had reclassification of tumor on repeat biopsy at year 5 to Gleason 4 + 3, and had a further upgrade at prostatectomy to organ-confined Gleason 4 + 5 tumor in the apex. The apex and the four cross sections (CS#1-CS#4) are depicted. Three tumor foci (two in the peripheral zone and one in the transition zone) are indicated with black, yellow, and green dots). All tumor foci are confined to the prostate. The location and Gleason score/grades and dimensions for each tumor focus is listed at the bottom. (A = anterior; LAL = left anterior lateral; LL = left lateral; LPL = left posterolateral; P = posterior; PZ = peripheral zone; L = left; TZ = transition zone; RL = right lateral; GS = Gleason score; GG = Gleason grade; Ca#1 = Gleason 4 + 5 tumor at the apex.)