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. 2016 Jan 12;108(4):djv360. doi: 10.1093/jnci/djv360

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© The Author 2016. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Combined sets. Kaplan-Meier estimates of the survival function for time to distant recurrence and overall survival for control and zoledronate arms. High signifies both macrophage-capping protein (CAPG) and PDZ domain–containing protein GIPC1 (GIPC1) high; low signifies other combinations where not both CAPG and GIPC1 are high. A and B) Skeletal only; first distant recurrence only skeletal. C and D) Skeletal and other; first report of distant recurrence included skeletal and other site(s) of metastasis. E and F) Nonskeletal; first distant recurrence does not contain any skeletal component. G and H) First skeletal recurrence irrespective of timing and sites of local and nonskeletal recurrences. I and J) Overall survival. P values refer to the two-sided log-rank test. DR = distant recurrence; OS = overall survival.