Table 3.
Predictors of cardiovascular events.
| Variable | Nonadjusted | Adjusted | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Male (yes) | 0.99 (0.51–1.95) | 1.00 | ||
| Age (yes) | 1.04 (1.01–1.07) | 0.01 | 1.02 (0.99–1.05) | 0.24 |
| Diabetes (yes) | 1.87 (0.97–3.60) | 0.06 | ||
| Smoking (yes) | 0.84 (0.42–1.65) | 0.61 | ||
| Systolic BP (mmHg) | 1.02 (0.99–1.04) | 0.12 | ||
| BMI (kg/m2) | 0.95 (0.86–1.05) | 0.35 | ||
| Plasma NGAL (ng/mL) | 1.005 (1.003–1.007) | <0.0001 | 1.004 (1.002–1.006) | <0.0001 |
| Urinary NGAL (μg/gCr) | 1.00 (0.999–1.001) | 0.71 | ||
| BNP (pg/mL) | 1.005 (1.003–1.006) | <0.0001 | 1.005 (1.003–1.007) | <0.0001 |
| eGFR (mL/min/1.73 m2) | 0.96 (0.93–0.99) | 0.002 | 0.99 (0.96–1.04) | 0.87 |
| Hemoglobin (g/dL) | 0.72 (0.60–0.85) | <0.0001 | 0.94 (0.78–1.14) | 0.54 |
| hsCRP (mg/L) | 1.78 (1.32–2.35) | <0.0001 | 1.33 (0.98–1.82) | 0.07 |
| UACR (g/gCr) | 1.26 (1.09–1.44) | 0.001 | 1.16 (0.97–1.39) | 0.09 |
| Triglyceride (mg/dL) | 0.99 (0.99–1.00) | 0.36 | ||
| LDL-C (mg/dL) | 1.00 (0.99–1.01) | 0.40 | ||
| HDL-C (mg/dL) | 0.99 (0.97–1.00) | 0.21 | ||
| LVH of ECGa | 1.75 (0.53–5.75) | 0.36 | ||
| ST-T change of ECGa | 1.14 (0.35–3.76) | 0.83 | ||
| EF of UCGb | 0.94 (0.88–1.00) | 0.056 | ||
| ARB or ACEi (yes) | 0.66 (0.33–1.30) | 0.23 | ||
| Statins (yes) | 0.96 (0.47–1.95) | 0.91 | ||
a n = 194; b n = 151.
Multivariate model includes all variables with P < 0.05 by univariate analysis.
ACEi, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; BMI, body mass index; BNP, B-type natriuretic peptide; BP, blood pressure; ECG, electrocardiogram; EF, ejection fraction; eGFR, estimated glomerular filtration rate; HDL-C, high-density lipoprotein-cholesterol; HR, hazard ratio; hsCRP, high-sensitivity C-reactive protein; LDL-C, low-density lipoprotein-cholesterol; LVH, left ventricular hypertrophy; NGAL, neutrophil gelatinase-associated lipocalin; UACR, urinary albumin creatinine ratio; UCG, ultracardiography.