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Embryonic death resulting from the combined loss of NF-κB1 and RelA or c-rel and RelA is overcome by blocking TNF-α signaling. (A) rela−/− nfκb1−/− tnfα−/− or rela−/− c-rel−/− tnfα−/− fetuses were isolated at E18 from the respective intercrosses of rela+/− nfκb1−/− tnfα−/− and rela+/− c-rel−/− tnfα−/− mice. (B to D) H&E-stained sections of dorsal skin from E18 fetuses. (B) rela+/+ c-rel−/− tnfα−/−, (C) rela−/−nfκb1−/− tnfα−/−, and (D) rela−/− c-rel−/− tnfα−/− genotypes. Bar, 425 μm.
