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. 2016 Jan 18;5(1):4. doi: 10.3390/antiox5010004

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Influence of NiO nanoparticle exposure on the gene expression of metallothionein in the lung. (A) mt1 and mt2 gene expression in the lung after intratracheal instillation and inhalation. The gene expression of mt was determined by real-time PCR. Values are mean ± SE (n = 5). Significant differences versus control group are indicated in the figure (ANOVA, Dunnet). ** p < 0.01, * p < 0.05; (B) Comparison of 0.2 mg intratracheal instillation and high dose inhalation. ** p < 0.01, * p < 0.05 (ANOVA, Tukey).

Influence of NiO nanoparticle exposure on the gene expression of metallothionein in the lung. (A) mt1 and mt2 gene expression in the lung after intratracheal instillation and inhalation. The gene expression of mt was determined by real-time PCR. Values are mean ± SE (n = 5). Significant differences versus control group are indicated in the figure (ANOVA, Dunnet). ** p < 0.01, * p < 0.05; (B) Comparison of 0.2 mg intratracheal instillation and high dose inhalation. ** p < 0.01, * p < 0.05 (ANOVA, Tukey).