Fig. 1.

Comparisons of NPPM 6748-481 docking poses in the hydrophobic pockets of Sec14 and Sfh1. A: Modeled NPPM 6748-481 poses within the hydrophobic pockets of Sec14 (left panel, blue) and Sfh1 (middle panel, black) are shown. Residues of interest are labeled. The right panel shows a superposition of the binding modes in the two distinct pocket environments and highlights the differences between the two binding modes. Sec14 residue F₂₂₈ is projected to stabilize NPPM binding via stacking interactions, and these interactions are not available in the Sfh1 context. B: Top views of NPPM-481 docked to Sec14 (left panel) and Sfh1 (right panel) are shown. The protein pocket is rendered in surface mesh with residues of interest highlighted in ball and stick representation.