FIG. 3.

MLL complex composition is conserved with yeast and human SET1 methyltransferase complexes. Similarities between components of the yeast SET1, human SET1/HCF-1, and human MLL/HCF complexes are shown. The protein components of each complex are shown schematically with structural domains and motifs as defined in the key at the bottom. RRM, RNA recognition motif; SET, Set domain; postSET, Set domain-associated cysteine-rich motif; PHD, PHD zinc-finger motif; SPRY, domain in SP1a and the Ryanodine receptor; RIIa, protein kinase A regulatory subunit dimerization domain motif.