Table 1.
Key model parameters for cost-impact model.
| Variable | Value | Lower Limit | Upper Limit | Source |
|---|---|---|---|---|
| Cost of IHC per sample (USA) | $89 | $54 | $124 | Lab. survey |
| Cost of IHC per sample (Europe) | $67.88 | $33 | $112.73 | Lab. survey |
| Cost of FISH per sample (USA) | $330 | $300 | $360 | Lab. survey |
| Cost of FISH per sample (Europe) | $197.72 | $169.09 | $244.20 | Lab. survey |
| IHC reimbursement (USA) | $90.46 | - | - | Medicare [17] |
| FISH reimbursement (USAA) | $216.35 | $214.52 | $217.38 | Medicare [17] |
| ALK testing reimbursement (Europe) | $155.50 | $132 | $186 | - |
| Probability of ALK+ result by IHC | 4.0% | 3.4% | 10.1% | Paik [18], Cabillic [19], Ali [20], Sullivan [21] |
| Probability of ALK+ result by FISH | 4.2% | 3.8% | 6.4% | Paik [18], Cabillic [19], Ali [20], Sullivan [21] |
| Probability of ALK+ result by either IHC or FISH | 4.9% | 3.8% | 10.1% | Paik [18], Cabillic [19], Ali [20], Sullivan [21] |
| Probability of ALK+ result by IHC but ALK− by FISH | 0.7% | 0.0% | 3.7% | Paik [18], Cabillic [19], Ali [20], Sullivan [21] |
| Failure rate of ALK IHC | 1.2% | - | - | Zhou [22] |
| Failure rate of ALK FISH | 6.6% | - | - | Zhou [22] |
IHC, immunohistochemistry; FISH, fluorescent in situ hybridization.