Currently taking HRT or alternative hormone therapy for the relief of postmenopausal symptoms or have done so in the last 6 months
Breast or cervical cancer
Other serious disease, such as cardiovascular disease, other cancer, kidney or liver disease or neurologic condition
Smokers or currently on nicotine therapy
Using insulin or warfarin therapy
Clinically significant depression
Currently consuming more than 4 alcoholic beverages a day
Changed medication in the 3 months prior to study enrolment
Clinic BP > 160/100 mmhg (determined at screening)
Suspected dementia (determined at screening)