Table 4.
The modulation of islet morphometry.
| Control (n = 8) | GEB-L (n = 8) | GEB-H (n = 8) | Positive-Control (n = 8) | |
|---|---|---|---|---|
| β-cell area (%) | 6.5 ± 0.8 b | 7.0 ± 0.9 a,b | 7.6 ± 0.9 a | 7.0 ± 0.9 a,b |
| Individual β-cell size (μm2) | 227 ± 28 a | 208 ± 26 a,b | 187 ± 25 b | 193 ± 27 b |
| Absolute β-cell mass (mg) | 18.7 ± 2.8 c | 23.3 ± 3.0 b | 28.8 ± 3.5 a | 23.8 ± 2.9 b |
| BrdU+ cells (% BrdU+ cells of islets) | 0.84 ± 0.10 b | 0.92 ± 0.12 b | 1.11 ± 0.12 a | 0.93 ± 0.12 b |
| Apoptosis (% apoptotic bodies of islets) | 0.70 ± 0.09 a | 0.65 ± 0.07 a,b | 0.59 ± 0.08 b | 0.61 ± 0.07 b |
Values are means ± standard deviation. Px rats fed a high fat diet supplemented with (1) 0.5% water extract of Gastrodia elata Blume (GEB-L); (2) 2% water extract of Gastrodia elata Blume (GEB-H); (3) 2% dextrin (Px-control); or (4) rosiglitazone (20 mg/kg body weight; positive-control) for 8 weeks. a,b,c Means on the same row with different superscripts were significantly different at p < 0.05.