Table 4.
The effect of confounding risk factors on the interaction between TLR4 rs10116253 and MyD88 rs7744 in the risk of CAD.
| TLR4 | MyD88 | Controls (n) | Cases (n) | Cases vs. Controls | Controls (n) | Cases (n) | Cases vs. Controls | ||
|---|---|---|---|---|---|---|---|---|---|
| rs10116253 | rs7744 | OR (95% CI) | p | OR (95% CI) | p | ||||
| H. pylori (−) a | H. pylori (+) a | ||||||||
| TC + CC | AA | 69 | 62 | 1 (ref.) | 54 | 39 | 1 (ref.) | ||
| TC + CC | AG + GG | 103 | 92 | 0.962 (0.430–2.153) | 0.925 | 76 | 77 | 1.076 (0.507–2.285) | 0.848 |
| TT | AA | 31 | 26 | 0.903 (0.361–2.260) | 0.828 | 20 | 30 | 1.594 (0.657–3.868) | 0.303 |
| TT | AG + GG | 36 | 61 | 1.825 (0.772–4.312) | 0.170 | 35 | 37 | 1.123 (0.493–2.562) | 0.782 |
| p = 0.082, OR (95% CI) = 2.032 (0.914–4.518) | p = 0.132, OR (95% CI) = 0.502 (0.205–1.231) | ||||||||
| Hyperglycemia (−) b | Hyperglycemia (+) b | ||||||||
| TC + CC | AA | 95 | 67 | 1 (ref.) | 28 | 34 | 1 (ref.) | ||
| TC + CC | AG + GG | 137 | 102 | 1.041 (0.518–2.092) | 0.910 | 42 | 67 | 1.384 (0.511–3.752) | 0.523 |
| TT | AA | 35 | 35 | 1.243 (0.556–2.781) | 0.597 | 16 | 21 | 0.955 (0.3026–3.023) | 0.937 |
| TT | AG + GG | 56 | 55 | 1.349 (0.633–2.875) | 0.439 | 15 | 43 | 2.744 (0.903–8.345) | 0.075 |
| p = 0.863, OR (95% CI) = 0.938 (0.450–1.953) | p = 0.348, OR (95% CI) = 1.683 (0.567–4.992) | ||||||||
| Hyperlipidemia (−) c | Hyperlipidemia (+) c | ||||||||
| TC + CC | AA | 68 | 52 | 1 (ref.) | 55 | 49 | 1 (ref.) | ||
| TC + CC | AG + GG | 102 | 71 | 1.026 (0.451–2.333) | 0.951 | 77 | 98 | 1.215 (0.542–2.720) | 0.637 |
| TT | AA | 28 | 26 | 1.217 (0.480–3.087) | 0.679 | 23 | 30 | 1.165 (0.427–3.178) | 0.765 |
| TT | AG + GG | 40 | 48 | 1.908 (0.758–4.807) | 0.170 | 31 | 50 | 1.513 (0.624–3.667) | 0.359 |
| p = 0.354, OR (95% CI) = 1.497 (0.637–3.517) | p = 0.688, OR (95% CI) = 0.837 (0.351–1.996) | ||||||||
a, these tests were adjusted by age, sex, hypertension, hyperglycemia and hyperlipidemia; b, these tests were adjusted by age, sex, hypertension, hyperlipidemia and H. pylori infection; c, these tests were adjusted by age, sex, hypertension, hyperglycemia and H. pylori infection; Statistically significant interactions were highlighted in bold (p value for interaction <0.05). CAD: coronary artery disease; TLR4: toll-like receptor 4; MyD88: myeloid differentiation factor 88; H. pylori: Helicobacter pylori; OR: odds ratio; CI: confidence interval.