Dose-response relationships between cumulative lead dust/fume exposure and lead poisoning and abnormal ZPP. (A) BMD and BMDL of cumulative lead dust for lead poisoning; (B) BMD and BMDL of cumulative lead dust for abnormal ZPP; (C) BMD and BMDL of cumulative lead fumes for lead poisoning; (D) BMD and BMDL of cumulative lead fumes for abnormal ZPP, where the X-axis (i.e., dose) represents cumulative lead dust/fume dose (mg·y/m3), and Y-axis (i.e., fraction affected) represented rates of lead poisoning (A,C) or abnormal ZPP (B,D). Abbreviations: ZPP, erythrocyte zinc protoporphyrin; BMD, benchmark dose; BMDL, benchmark dose lower bound.