Table 5. Cardiomyopathy and Valvular Disease by Cardiac Risk Factors* †.
| Cardiomyopathy | Valvular disease | |||
|---|---|---|---|---|
| OR* | 95% CI | OR* | 95% CI | |
|
|
||||
| Sex | ||||
| Female | 1.0 | 1.0 | ||
| Male | 1.9 | (1.1-3.3) | 0.8 | (0.6-1.0) |
| Age at Diagnosis (years) | ||||
| 0-4 | 0.5 | (0.3-1.1) | 1.5 | (1.1-2.2) |
| 5-9 | 0.6 | (0.3-1.2) | 1.3 | (0.9-1.9) |
| 10-14 | 0.9 | (0.5-1.7) | 1.0 | (0.7-1.5) |
| ≥ 15 | 1.0 | 1.0 | ||
| Age at SJLIFE Evaluation (years) | ||||
| 18-29 | 1.0 | 1.0 | ||
| 30-39 | 1.3 | (0.7-2.3) | 0.8 | (0.6-1.1) |
| ≥ 40 | 0.4 | (0.2-1.0) | 1.2 | (0.8-1.7) |
| BMI at SJLIFE assessment (kg/m2) | ||||
| Normal/underweight | 1.0 | 1.0 | ||
| Overweight (BMI=25.0 to <30) | 1.0 | (0.5-1.9) | 0.8 | (0.6-1.1) |
| Obese (BMI ≥ 30) | 1.2 | (0.6-2.3) | 0.4 | (0.3-0.6) |
| Anthracycline (mg/m2) | ||||
| None | 1.0 | - | -- | |
| < 250 | 1.2 | (0.5-2.8) | - | -- |
| ≥ 250 | 2.7 | (1.1-6.9) | - | -- |
| Average Cardiac Radiation dose (cGy) | ||||
| None | 1.0 | - | -- | |
| ≤ 1500 | 1.1 | (0.5-2.2) | - | -- |
| > 1500 | 1.9 | (1.1-3.7) | - | -- |
| Interaction Cardiac Radiation * Anthracycline | ||||
| ≤ 1500 cGy * No anthracycline | 1.0 | |||
| > 1500 cGy * ≥ 250 mg/m2 anthracycline | N/A | 4.5 | (1.9-10.7) | |
| ≤ 1500 cGy * ≥ 250 anthracycline | 0.9 | (0.3-2.3) | ||
| No radiation * ≥ 250 anthracycline | 1.1 | (0.6-2.2) | ||
| > 1500 cGy * ˂ 250 mg/m2 anthracycline | 3.1 | (1.5-6.2) | ||
| ≤ 1500 cGy * ˂ 250 mg/m2 anthracycline | 1.9 | (1.0-3.8) | ||
| No radiation * ˂ 250 mg/m2 anthracycline | 1.1 | (0.6-2.0) | ||
| > 1500 cGy * no anthracycline | 4.1 | (2.1-8.0) | ||
| Smoker (ever) | ||||
| No | 1.0 | 1.0 | ||
| Yes | 0.9 | (0.5-1.5) | 0.8 | (0.6-1.0) |
| Physical Activity | ||||
| Inactive | 1.0 | 1.0 | ||
| Active | 1.2 | (0.7-2.0) | 1.0 | (0.8-1.3) |
| Excessive alcohol | ||||
| No | 1.0 | 1.0 | ||
| Yes | 0.9 | (0.5-1.5) | 1.0 | (0.8-1.3) |
| Hypertension | ||||
| No | 1.0 | 1.0 | ||
| Yes | 3.0 | (1.7-5.2) | 1.2 | (0.9-1.7) |
| Diabetes | ||||
| No | 1.0 | 1.0 | ||
| Yes | 2.0 | (0.9-4.2) | 0.7 | (0.4-1.3) |
| Dyslipidemia | ||||
| No | 1.0 | 1.0 | ||
| Yes | 1.0 | (0.6-1.7) | 0.7 | (0.6-0.9) |
*
Estimates adjusted for all variables in the table.
†
Analysis limited to only those outcomes detected at baseline SJLIFE visit. SJLIFE = St. Jude Lifetime Cohort, BMI = body mass index, cGy = centigray