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Effect of MC treatment on CA9 promoter activity in HCT 116 p53+/+ and p53−/− cells. Cells were cotransfected with the [−173, +31] CA9 reporter construct and pRL-tk as in Fig. 2. CA9 promoter activity in p53+/+ cells under normoxic conditions was set as 1, and the rest is expressed as the level of induction as in Fig. 2.
