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. 2004 Jul;24(13):5887–5899. doi: 10.1128/MCB.24.13.5887-5899.2004

FIG. 10.

FIG. 10.

Diagram of germ cell progression, corresponding to spermatogenesis phase and tubule stages. The black boxes at the top represent the stage showing expression of TR4; end of meiotic prophase-expressed genes sperm 1 and cyclin A1; premeiosis-expressed genes proacrosin, Hsp 70-2, and histone H1t; postmeiosis-expressed genes TP1, TP2, Prm 1, and Prm 2. Note that in TR4−/− mice, late meiotic prophase and subsequent meiotic divisions in late pachytene diplotene and metaphase spermatocytes of tubule stages X to XII were delayed, prolonged, and disrupted. A, type A spermatogonia; In, intermediate spermatogonia; B, type B spermatogonia; PL, preleptotene spermatocytes; L, leptotene spermatocytes; Zs, zygotene spermatocytes; EPs, early pachytene spermatocytes; LPs, late pachytene spermatocytes; Ds, diplotene spermatocytes; MI, first meiosis; MII, second meiosis; Rs, round spermatids; Es, elongated spermatids; S16, step 16 spermatids; E, early; L, late.