Skip to main content
. Author manuscript; available in PMC: 2016 Jul 22.
Published in final edited form as: Adv Mater. 2015 Jun 12;27(28):4207–4212. doi: 10.1002/adma.201500752

Figure 1.

Figure 1

Design of synthetic nucleoporin-like polypeptide hydrogels. a) A sequence logo diagram of the natural nucleoporin, cNsp1 (Nsp1282-585). Color codes represent amino acids with hydrophobic side chains (black), polar side chain (green), negatively charged side chain (red) and positively charged side chain (blue). b) Primary structure for 1NLP and 2NLP, consensus sequences of cNsp1. c) Design of synthetic protein polymers, P-cNsp1-P and P-NLPs-P, which gel by the association of pentameric (P) coiled-coil endblock domains. Red filled circles represent FG sequences. d) 3D gel network formed from assembly of designed artificially engineered proteins. Black dotted circles highlight Phe-mediated interactions within synthetic hydrogels.