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. Author manuscript; available in PMC: 2016 Mar 28.
Published in final edited form as: Bone Marrow Transplant. 2015 May 18;50(9):1157–1167. doi: 10.1038/bmt.2015.61

Table 4.

Summary of studies comparing RIC with MAC regimens

Study Disease RIC vs MAC aGvHD 2–4 (%) RIC vs MAC cGvHD (%) RIC vs MAC NRM (%) RIC vs MAC Relapse (%) RIC vs MAC PFS (%) RIC vs MAC OS (%)
Olle Ringden68 AML 31 vs 36 31 vs 38 HR 0.85 HR 1.46 HR 0.88 NR
AML 29 vs 29 36 vs 46 HR 0.64 HR 1.34 HR 1.04 NR
Shimoni A69 AML 8 vs 22 31 vs 56 22 vs 8 14 vs 9 45 vs 49 50 vs 49 (2 yr) P = NS
Flynn CM70 AML 22 vs 17 13 vs 18 34 vs 33 RR 2.2 31 vs 30 33 vs 35 (2 yr) P>0.1
Aoudjhane M71 AML 22 vs 31 48 vs 56 32 vs 18 41 vs 24 40 vs 47 44 vs 46 (2 yr) P = NS
Martino63 AML/MDS 43 vs 58 45 vs 52 32 vs 22 26 vs 40 33 vs 39 41 vs 45 (3 yr) P = 0.8
Luger64 AML/MDS 41 vs 45 40 vs 35 RR 0.9 39 vs 32 NR 33 vs 34 (5 yr) P = NS
Scott65 AML/MDS 54 vs 78 55 vs 64 41 vs 34 31 vs 23 27 vs 44 28 vs 48 (3 yr) P = 0.56
Alyea27 AML/MDS 26 vs 27 33 vs 18 15 vs 32 61 vs 38 20 vs 31 34 vs 28 (2 yr) P = 0.056
Eom85 ALL 51 vs 52 61 vs 50 21 vs 24 34 vs 26 51 vs 55 HR 0.98 (5 yr) P = 0.30
Marks86 ALL 39 vs 46 34 vs 42 32 vs 33 35 vs 26 32 vs 41 38 vs 43 (3 yr) P = 0.39
Mohty87 ALL Similar Similar 21 vs 29 47 vs 31 32 vs 38 45 vs 48 (2 yr) P = 0.23
Bachanova88 ALL 46 vs 41 63 vs 45 13 vs 36 49 vs 28 26 vs28 39 vs 35 (3 yr) P = 0.62
Crawley113 Myeloma 35 vs 46 Similar 24 vs 37 19 vs 34 38 vs 51 (2 yr) P = NS
Hari123 FL 44 vs 36 62 vs 46 23 vs 23 RR 2.97 55 vs 67 62 vs 71 (3 yr) P = 0.15
Hamadani128 MCL 37 vs 36 43 vs 35 43 vs 47 32 vs 33 25 vs 20 30 vs 25 (3 yr) P = 0.45
Peres107 CLL 39 vs 55 38 vs 48 14 vs 27 15 vs 14 NR 63 vs 18 (5 yr) P = 0.006
Brown108 CLL 30 vs 50 NR 46 vs 9.5 7 vs 26 NR 63 vs 49 (5 yr) P = 0.003
Sureda133 HL 44 vs 53 38 vs 40 23 vs 46 57 vs 30 18 vs 20 28 vs 22 (5 yr) P = 0.04
Bacher125 DLBCL 43 vs 43 42 vs 37 47 vs 56 38 vs 26 15 vs 18 20 vs 18 (5 yr) P = NR

Abbreviations: aGvHD = acute GvHD; cGvHD = chronic GvHD; DLBCL = diffuse large B-cell lymphoma; FL = follicular lymphoma; HL = Hodgkin’s lymphoma; HR = hazard ratio; MAC = myeloablative conditioning; MCL = mantle cell lymphoma; MDS = myelodysplastic syndrome; mo = months; NR = not reported; NRM = nonrelapse mortality; OS = overall survival; RIC = reduced intensity conditioning; yr = years.