Table 2.

Logistic Regression Analysis of Genetic Predictors of Postoperative Atrial Fibrillation in the Study Populations

						DISCOVERY DATASET				REPLICATION DATASET				Combined
						MAF				MAF
Chr	SNP	BP	Gene symbol*	Minor allele	Major allele	No PoAF	Yes PoAF	OR (95%CI)	P‡	No PoAF	Yes PoAF	OR (95%CI)	P‡	Meta-P
2	rs880726#	236343827	SH3BP4 I AGAP1	A	C	0.15	0.23	1.98 (1.47–2.66)	5.9×10−6	0.19	0.17	1.15 (0.67–1.97)	0.62	2.5×10−5
3	rs17711446#	55534264	LOC100289467 I ERC2	A	G	0.11	0.18	2.12 (1.51–2.97)	1.2×10−5	0.13	0.16	1.46 (0.79–2.69)	0.22	1.0×10−5
4	rs4425335#	169618128	PALLD	G	A	0.22	0.31	1.75 (1.34–2.28)	4.2×10−5	0.29	0.23	1.04 (0.64–1.69)	0.88	0.0002
6	rs6455	32006896	CYP21A2*	G	C	0.015	0.047	5.61 (2.75–11.42)	2.1×10−6	0.025	0.029	1.96 (0.51–7.58)	0.33	3.2×10−6
6	rs9349540#	50364629	DEFB112 I TFAP2D	G	A	0.35	0.25	0.58 (0.45–0.75)	4.6×10−5	0.31	0.31	0.96 (0.60–1.54)	0.86	0.0003
8	rs10504554	74919713	LY96	G	A	0.18	0.12	0.48 (0.34–0.68)	2.9×10−5	0.18	0.17	0.55 (0.31–0.99)	0.046	4.0×10−6
9	rs7870498	77146468	RORB	G	A	0.49	0.38	0.59 (0.46–0.74)	1.0×10−5	0.49	0.48	0.85 (0.57–1.27)	0.42	2.5×10−5
9	rs1323369#	77148835	RORB	G	A	0.49	0.38	0.59 (0.47–0.75)	1.4×10−5	0.5	0.48	0.82 (0.54–1.23)	0.33	2.2×10−5
10	rs11015781#	18994583	ARL5B I LOC100130846	A	C	0.3	0.4	1.84 (1.43–2.37)	2.6×10−6	0.32	0.34	1.2 (0.76–1.91)	0.44	7.1×10−6
10	rs2210723#	110233497	LOC100128304 I LOC645318	G	A	0.062	0.11	2.41 (1.60–3.63)	2.6×10−5	0.08	0.077	0.92 (0.44–1.93)	0.82	0.0004
10	rs12242854#	110259916	LOC100128304 I LOC645318	A	G	0.062	0.11	2.41 (1.60–3.63)	2.8×10−5	0.08	0.077	0.91 (0.44–1.92)	0.82	0.0004
12	rs4760332	58222672	CTDSP2	A	C	0.28	0.38	1.7 (1.34–2.16)	1.4×10−5	0.31	0.31	0.78 (0.48–1.22)	0.26	0.0008
12	rs10783850	58229377	CTDSP2	G	A	0.28	0.38	1.65 (1.30–2.09)	4.7×10−5	0.31	0.31	0.75 (0.47–1.19)	0.22	0.002
14	rs2241121	89826113	FOXN3	A	G	0.21	0.13	0.49 (0.35–0.68)	2.1×10−5	0.22	0.16	0.67 (0.38–1.17)	0.16	1.1×10−5
14	rs1612612#	93497111	ITPK1 I C14orf85	A	G	0.24	0.33	1.73 (1.33–2.25)	4.1×10−5	0.26	0.21	0.58 (0.34–0.98)	0.04	0.006
17	rs1399293	63254424	RGS9 I AXIN2	G	A	0.12	0.06	0.35 (0.23–0.55)	4.9×10−5	0.071	0.13	1.74 (0.92–3.31)	0.09	0.0055
17	rs16961956#	63259951	RGS9 I AXIN2	A	G	0.11	0.06	0.36 (0.23–0.57)	1.3×10−5	0.071	0.12	1.61 (0.84–3.07)	0.15	0.006
17	rs17763241	63257153	RGS9 I AXIN2	A	G	0.11	0.06	0.38 (0.24–0.59)	2.6×10−5	0.71	0.12	1.61 (0.84–3.08)	0.15	0.009
20	rs6099823	56469998	PMEPA1 I LOC100129869	A	G	0.07	0.13	2.21 (1.51–3.22)	4.1×10−6	0.12	0.054	0.38 (0.16–0.88)	0.02	0.005

Chr, chromosome; MAF, minor allele frequency in cases and controls; OR, multivariate odds ratio; PoAF, postoperative atrial fibrillation; SNP, single-nucleotide polymorphism

^*Intergenic region is expressed with “|” between two franking genes; SNP rs6455 in CYP21A2 is a coding SNP.

^‡Adjusted for postoperative atrial fibrillation risk index as a continuous variable.

^#Indicates imputed markers in the CATHGEN cohort